Skin and V D Questions and Answers

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Questions and Answers on Skin and V D

1. The components of Michel’s medium are all, except –
(1) Potassium citrate
(2) Sodium chloride
(3) Magnesium sulphate
(4) Ethylmaleimide

2. Inheriting one filaggrin gene mutation has been found to increase the risk of Atopic Eczema six fold, whereas inheriting two filaggrin mutations increase the risk by –
(1) 12 fold
(2) 100 fold
(3) 120 fold
(4) 150 fold

3. The pathogenesis of DRESS is –
(1) B-cell mediated
(2) IgE-mediated
(3) Immune complex mediated
(4) T-cell mediated

4. Lethal effective dose is defined as a dose of drug required to cause death in how many percentage of experimental animals (pre-clinical)?
(1) 20%
(2) 50%
(3) 30%
(4) 60%

5. The development of Pilosebaceous unit takes place in the following gestational age –
(1) 8-10 weeks
(2) 10-14 weeks
(3) 15-17 weeks
(4) 18-20 weeks

6. Type IV collagen is found –
(1) in dermis and accounts for 80% of total collagen
(2) in dermis and accounts for 10% of total collagen
(3) in basement membrane within dermo-epidermal junction and vascular basement membrane
(4) as major component of anchoring fibrils

7. Transmembrane glycoprotein P-selectin is stored in –
(1) Neutrophils & eosinophils
(2) Basophil
(3) Platelets and endothelial cells
(4) Lymphocytes and monocytes

8. In vivo source of IL-20 cytokine is –
(1) Fibroblasts
(2) Keratinocytes
(3) Monocytes
(4) Dendritic cells

9. Acute generalized exanthematous pustulosis is a clinical pattern of which form of type IV hypersensitivity reaction?
(1) Type IVA
(2) Type IVB
(3) Type IVC
(4) Type IVD

10. Merkel cells are mechanoreceptors found in area of high-tactile sensitivity. This immunohistochemical marker is restricted to Merkel cells in the skin and is thus a reliable marker for these cells –
(1) Keratin 7
(2) Keratin 20
(3) S-100
(4) Factor XIII a

11. In a topical skin preparation, all are the constituents of Lipid vehicles, except –
(1) Castor oil
(2) Cetyl alcohol
(3) Glycerine
(4) Cocoa butter

12. One fingertip unit in topical medications is approximately about in adult male/female –
(1) 02-0.3g
(2) 0.4-0.5g
(3) 0.6-0.7g
(4) 1.0g

13. The most common ocular symptoms associated with antimalarials is –
(1) Central visual field loss
(2) Visual halos
(3) Watering of eyes
(4) Difficulty with reading

14. An 80 year old female presents with a slowly growing papule on her nasal lip for 2yrs. It was asymptomatic to start with, now became sore and bleeds occasionally. On H/P examination reveals Basaloid island with peripheral palisading. What treatment has the highest cure rate?
(1) Electrodesiccation and curettage
(2) Cryotherapy
(3) Mohs micrographic surgery
(4) CO2 laser

15. Which Q switched laser works on yellow tattoo ink?
(1) Nd-YAG (1064 nm)
(2) Nd-YAG (532 nm)
(3) Alexandrite (755 nm)
(4) Ruby (694 nm)

16. Wavelength for laser-assisted lipolysis is –
(1) 10600 nm
(2) 1440/924/975 nm
(3) 2940 nm
(4) 1064 nm

17. Which of the following is not a symptom of steroid withdrawal syndrome?
(1) Postural hypotension
(2) Hyponatraemia
(3) Increased appetite
(4) Hyperkalaemia

18. Which of the following chemical agents protect against UVA light only?
(1) Octocrylene
(2) PABA
(3) Dibenzoylmethanes
(4) Benzophenones

19. Original Kligman formulation (1975) for depigmentation has the following components –
(1) 2% hydroquinone, 0.1% tretinoin, 0.1% dexamethasone
(2) 5% hydroquinone, 0.05% tretinoin, 0.1% dexamethasone
(3) 5% hydroquinone, 0.1% tretinoin, 0.5% dexamethasone
(4) 5% hydroquinone, 0.1% tretinoin, 0.1% dexamethasone

20. Which of the following is not used as psoriasis assessment tool?
(1) Psoriasis Area and Severity Index (PASI)
(2) Physician’s Global Assessment (PGA)
(3) Lattice system global assessment
(4) Rajka langeland severity classification

21. Linder diagnostic scoring system is used for –
(1) MB Relapse
(2) PB Relapse
(3) MB Reactivation
(4) PB Reactivation

22. According to Indian Association of Leprologists 1981, leprosy is divided into how many types?
(1) 3
(2) 4
(3) 5
(4) 6

23. Which of the following test is not used for leprosy?
(1) Lepromin test
(2) Sweating test
(3) Histamine test
(4) Serotonin test

24. Which statement is true regarding Erythema Nodosum Leprosum?
(1) Activation of Th1, increase IL-2, IFN-γ.
(2) Activation of Th2, increase IL-4, 5, 13, 10 cytokine.
(3) Augmented humoral immunity and elevated complement level C3.
(4) Positive Medina test.

25. Anhidrosis is characteristic of skin lesion of which type of leprosy?
(1) Tuberculoid leprosy
(2) Borderline lepromatous leprosy
(3) Mid-borderline leprosy
(4) Lepromatous leprosy

26. Which sign in congenital syphilis is most specific?
(1) Syphilitic paronychia
(2) Pemphigus syphiliticus
(3) Snuffler
(4) Wimberger sign

27. A 32-year-old female comes to skin OPD with chief complain of copious homogeneous malodorous yellowish-greenish discharge and on colposcopy, punctate mucosal hemorrhage are present. Which organism could result in this type of vaginosis?
(1) Candida
(2) Trichomonas vagnalis
(3) Gardnerella vaginalis
(4) Neisseria gonorrhoeae

28. A 27-year-old male comes to skin OPD with well-defined granulomatous ulcer which is painless, beefy red in color and bleeds easily on touch on examination lymph nodes are not palpable. Identify the disease.
(1) Donovanosis
(2) Herpes genitalis
(3) Syphilis
(4) Chancroid

29. Which is not a part of Amsel criteria to diagnose bacterial vaginosis?
(1) Elevated vaginal pH
(2) Clue cell
(3) Excessive homogeneous uniformly adherent discharge
(4) Lowered vaginal pH

30. Nugent scoring is used to diagnose which condition?
(1) Herpes genitalis
(2) Syphilis
(3) Bacterial vaginosis
(4) Trichomoniasis

31. Coral-red fluorescence of erythrasma under wood light is attributed to –
(1) Protoporphyrin IX
(2) Uroporphyrinogen
(3) Coproporphynin TI
(4) Porphobilinogen

32. All of the following causes Cutaneous Larva Migrans, except –
(1) Ancylostoma
(2) Uncinaria
(3) Bunostomum
(4) Strongyloides

33. A 28-year-old male presented to skin OPD with filiform, keratotic papule, protruding through follicle on nose. On HPE follicles are enlarged with keratinocyte enlarged with cytoplasmic inclusion bodies and trichohyaline granule. Electron microscopy shows a densely packed viral particle array in keratinized cell within follicles. What is causative agent of study?
(1) Papilloma virus
(2) Polyoma virus
(3) Pox virus
(4) Herpes virus

34. Most common predisposing condition for Kaposi’s varicelliform eruption is –
(1) Nummular eczema
(2) Atopic eczema
(3) Ichthyosis vulgaris
(4) Hailey-Hailey Disease

35. Dermoscopy of scabies burrows shows which of the following sign?
(1) Jet with contrail
(2) Hem-like pattern
(3) Starburst pattern
(4) Fish in pond

36. Causative agent of Deep Myrmecial Wart is –
(1) HPV-1
(2) HPV -2
(3) HPV -4
(4) HPV -27

37. What is TRUE for carrion disease?
(1) Internal stage is characterized by erythematous papules which appear in crops and later become nodular.
(2) Verruca peruana has sudden onset of pyrexia accompanied by haemolytic anaemia.
(3) Different state of evolution may be present in same patient.
(4) Cotrimoxazole is treatment of choice.

38. Twisted fingers in leprosy is a –
(1) Specific deformity
(2) Paralytic deformity
(3) Vascular deformity
(4) Anaesthetic deformity

39. Diamond, Feinberg, Withington and Kupferberg are media used for culturing which organism?
(1) Gonococci
(2) Candida
(3) Trichomonas vaginalis
(4) Haemophilus Ducreyi

40. Variola (smallpox) species of human poxvirus belong to genus –
(1) Parapoxvirus
(2) Orthopoxvirus
(3) Yatapoxvirus
(4) Mbolluscipoxvirus

41. Causative microorganism for Yaws is –
(1) Treponema Carateum
(2) Treponema Pallidum
(3) Treponema Pertenue
(4) Treponema Endemicum

42. National leprosy eradication program was launched in which year?
(1) 1955-56
(2) 1983-84
(3) 1991-92
(4) 2007-08

43. Which of the following serological test is most sensitive in untreated primary syphilis?
(1) VDRL
(2) FYA-ABS
(3) Enzyme Immunoassay
(4) Rapid Plasma Reagin

44. Wimberger’s sign syphilitic infection is seen in –
(1) Late congenital syphilis
(2) Early congenital syphilis
(3) Secondary syphilis
(4) Tertiary syphilis

45. Which of the following NNRTI (Non-Nucleoside Reverse Transcriptase Inhibitor) cause fatal hepatitis?
(1) Efavirenz
(2) Nevirapine
(3) Rilpivirine
(4) Delavirdine